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Recent Publications

  1. Han X, Xiao Z, Quarles LD. Membrane and Integrative Nuclear Fibroblastic Growth Factor Receptor (FGFR) Regulation of FGF-23. J Biol Chem. 2015 Apr 17;290(16):10447-59. doi: 10.1074/jbc.M114.609230. Epub 2015 Mar 9. PMID: 25752607. PMCID:PMC4400353.
  2. Xiao Z, Quarles LD. Physiological mechanisms and therapeutic potential of bone
    mechanosensing. Rev Endocr Metab Disord. 2015 Jun;16(2):115-29. PubMed PMID: 26038304.
  3. Ezumba II, Gosmanova EO, Quarles LD, Wall BM. Severe Azotemia and Hyperchloremic Metabolic Acidosis Associated With Reverse Flow Enterovesical Fistula. Am J Med Sci. 2015 Sep 28. PubMed PMID: 26422804.
  4. Fajol A, Chen H, Umbach AT, Quarles LD, Lang F, Föller M. Enhanced FGF23 production in mice expressing PI3K-insensitive GSK3 is normalized by β-blocker treatment. FASEB J. 2016 Feb; 30(2):994-1001. doi: 10.1096/fj.15-279943. Epub 2015 Nov 2. PMID: 26527066
  5. Pi M, Kapoor K, Wu Y, Ye R, Senogles SE, Nishimoto SK, Hwang DJ, Miller DD, Narayanan R, Smith JC, Baudry J, Quarles LD. Structural and Functional Evidence for Testosterone Activation of GPRC6A in Peripheral Tissues. Mol Endocrinol. 2015 Dec; 29(12):1759-73. doi: 10.1210/me.2015-1161. Epub 2015 Oct 6. PMID: 26440882
  6. Han X, Li L, Yang J, King G, Xiao Z, Quarles LD. Counter-regulatory paracrine actions of FGF-23 and 1,25(OH)2 D in macrophages. FEBS Lett. 2016 Jan; 590(1):53-67. doi: 10.1002/1873-3468.12040. Epub 2016 Jan 9. PMID: 26762170
  7. Nayani SS, Xiao ZS. Recent Advances in Fibro-blast Growth Factor-23 Functions. Nephrol Open J. 2016,1(3):51-58. doi: 10.17140/NPOJ-1-110.
  8. Wang X, Pandey AK, Mulligan MK, Williams EG, Mozhui K, Li Z, Jovaisaite V, Quarles LD, Xiao Z, Huang J, Capra JA, Chen Z, Taylor WL, Bastarache L, Niu X, Pollard KS, Ciobanu DC, Reznik AO, Tishkov AV, Zhulin IB, Peng J, Nelson SF, Denny JC, Auwerx J, Lu L, Williams RW. Joint mouse-human phenome-wide association to test gene function and disease risk. Nat Commun. 2016 Feb 2; 7:10464. doi: 10.1038/ncomms10464. PMID: 26833085
  9. Kovesdy CP, Quarles LD. FGF23 from bench to bedside. Am J Physiol Renal Physiol. 2016 Jun 1;310(11):F1168-74. doi: 10.1152/ajprenal.00606.2015. Epub 2016 Feb 10. PMID: 26864938
  10. Han X, Yang J, Li L, Huang J, King G, Quarles LD. Conditional Deletion of Fgfr1 in the Proximal and Distal Tubule Identifies Distinct Roles in Phosphate and Calcium Transport. PLoS One. 2016 Feb 3; 11(2):e0147845. doi: 10.1371/journal.pone.0147845. eCollection 2016. PMID: 26839958
  11. Pi M, Kapoor K, Ye R, Nishimoto SK, Smith JC, Baudry J, Quarles LD. Evidence for Osteocalcin Binding and Activation of GPRC6A in β-Cells. Endocrinology. 2016 May;157(5):1866-80. doi: 10.1210/en.2015-2010. Epub 2016 Mar 23. PMID: 27007074.
    PMCID: PMC4870875. DOI. 10.1210/en.2015-2010
  12. Han X, Quarles LD. Multiple faces of fibroblast growth factor-23. Curr Opin Nephrol Hypertens. 2016 Jul;25(4):333-42. doi: 10.1097/MNH.0000000000000240. PMID: 27219044. PMCID: PMC5051268
  13. Ye R, Pi M, Cox JV, Nishimoto SK, Quarles LD. CRISPR/Cas9 targeting of GPRC6A suppresses prostate cancer tumorigenesis in a human xenograft model. J Exp Clin Cancer Res. 2017 Jun 28;36(1):90. doi: 10.1186/s13046-017-0561-x. PMID: 28659174. PMCID: PMC5490090. DOI:10.1186/s13046-017-0561-x
  14. Liu X, Chen Y, McCoy CW, Zhao T, Quarles DL, Pi M, Bhattacharya SK, King G, Sun Y. Differential Regulatory Role of Soluble Klothos on Cardiac Fibrogenesis in Hypertension. Am J Hypertens. 2016 Oct;29(10):1140-7. doi: 10.1093/ajh/hpw062. Epub 2016 Aug 19. PMID: 27543985
  15. Thomas Clemens, Qian Zhang, Michele Doucet, Ryan Tomlinson, Xiaobin Han, L. Darryl Quarles, and Michael Collins. The Hypoxia-Inducible Factor-1α Activates Ectopic Production of Fibroblast Growth Factor 23 in Tumor-induced Osteomalacia. Bone Res. 2016 Jul 5;4:16011. doi: 10.1038/boneres.2016.11. eCollection 2016. PMID: 27468359. PMCID: PMC4948305
  16. Xiao Z, Riccardi D, Velazquez HA, Chin AL, Yates CR, Carrick JD, Smith JC, Baudry J, Quarles LD. A computationally identified compound antagonizes excess FGF-23 signaling in renal tubules and a mouse model of hypophosphatemia. Sci Signal. 2016 Nov 22;9(455):ra113. PMID: 27879395. DOI: 10.1126/scisignal.aaf5034.
  17. Pi M, Nishimoto SK, Quarles LD. GPRC6A: Jack of all metabolism (or master of none). Mol Metab. 2016 Dec 21;6(2):185-193. doi: 10.1016/j.molmet.2016.12.006. eCollection 2017 Feb. PMID: 28180060. PMCID: PMC5279936. DOI:10.1016/j.molmet.2016.12.006. Jan;29(1):69-80. doi: 10.1681/ASN.2017040412. Epub 2017 Oct 9. PMID:28993502
  18. Quarles LD. FGF-23 Counter-Regulatory Hormone for Vitamin D Actions on Mineral Metabolism, Hemodynamics, and Innate Immunity. Vitamin D: Fourth Edition. Volume 1, December 2017, page 871-884.
  19. Impairment of primary cilia contributes to visceral adiposity of high fat diet-fed mice. Qiu N, Fang WJ, Li HS, He ZM, Xiao ZS, Xiong Y. J Cell Biochem. 2018 Feb;119(2):1313-1325. doi: 10.1002/jcb.26253. Epub 2017 Nov 14. PMID: 28671279.
  20. Velazquez HA, Riccardi D, Xiao Z, Quarles LD, Yates CR, Baudry J, Smith JC. Ensemble docking to difficult targets in early-stage drug discovery: Methodology and application to fibroblast growth factor 23.Chem Biol Drug Des. 2018 Feb;91(2):491-504. doi: 10.1111/cbdd.13110. Epub 2017 Nov 3. PMID: 28944571.DOI:10.1111/cbdd.13110.
  21. Xiao Z, Baudry J, Cao L, Huang J, Chen H, Yates CR, Li W, Dong B, Waters CM, Smith JC, Quarles LD. Polycystin-1 interacts with TAZ to stimulate osteoblastogenesis and inhibit adipogenesis. J Clin Invest. 2018 Jan 2;128(1):157-174. doi: 10.1172/JCI93725. Epub 2017 Nov 27. PMID:29202470
  22. Han X, Ross J, Kolumam G, Pi M, Sonoda J, King G, Quarles LD. Cardiovascular Effects of Renal Distal Tubule Deletion of the FGF Receptor 1 Gene. J Am Soc Nephrol. 2018
  23. Pi M, Kapoor K, Ye R, Smith JC, Baudry J, Quarles LD. GPCR6A is a Molecular Target for the Natural Products Gallate and EGCG in Green Tea. Mol Nutr Food Res. 2018 Feb 21. doi: 10.1002/mnfr.201700770. PMID:29468843
  24. Kovesdy CP, Lu JL, Wall BM, Gyamlani G, Naseer A, Wallick A, Han Z, Thomas F, Quarles LD, Jarmukli N. Changes With Lanthanum Carbonate, Calcium Acetate, and Phosphorus Restriction in CKD: A Randomized Controlled Trial. Kidney Int Rep. 2018 Mar 23;3(4):897-904. doi: 10.1016/j.ekir.2018.03.011. eCollection 2018 Jul. PMID:29989014
  25. Pi M, Kapoor K, Ye R, Hwang DJ, Miller DD, Smith JC, Baudry J, Quarles LD. Computationally identified novel agonists for GPRC6A. PLoS One. 2018 Apr 23;13(4):e0195980. doi: 10.1371/journal.pone.0195980. eCollection 2018. PMID: 29684031
  26. Fitzpatrick EA, Han X, Xiao Z, Quarles LD. Role of Fibroblast Growth Factor-23 in Innate Immune Responses. Front Endocrinol (Lausanne). 2018 Jun 12;9:320. doi: 10.3389/fendo.2018.00320. eCollection 2018. Review. PMID:29946298
  27. Pi M, Ye R, Han X, Armstrong B, Liu X, Chen Y, Sun Y, Quarles LD. Cardiovascular Interactions between Fibroblast Growth Factor-23 and Angiotensin II. Sci Rep. 2018 Aug 17;8(1):12398. doi: 10.1038/s41598-018-30098-1. PMID:30120363
  28. Quarles LD. Fibroblast growth factor 23 and α-Klotho co-dependent and independent functions. Curr Opin Nephrol Hypertens. 2018 Nov 16. doi: 10.1097/MNH.0000000000000467. PMID: 30451736.
  29. Ann Laszczyk, Dailey Nettles, Tate Pollock, Stephanie Fox, Melissa Garcia, Jing Wang, L. Quarles, and Gwendalyn King. FGF-23-deficiency impairs hippocampal-dependent cognitive function. eNeuro. 2019 Feb 13.
  30. Ye R, Pi M, Nooh MM, Bahout SW, and Quarles LD. Human GPRC6A mediates testosterone-induced ERK and mTORC1 signaling. Mol Phar 95:563-572, 2019.